Background：The innate immune system recognizes microbial pathogens through Toll-like receptors （TLRs）, which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor （TIR） domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
仕様
Synonyms：Adapter protein wyatt,FLJ42305,MAL,MyD88 adapter like protein,TIR domain containing adapter protein,Toll interleukin 1 receptor （TIR） domain containing adaptor protein,Toll interleukin 1 receptor domain containing adapter protein,Toll like receptor adaptor protein,Wyatt
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human TIRAP around the phosphorylation site of Tyr86
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
