Background：Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
仕様
Synonyms：60 kDa Tat interactive protein,60 kDa Tat-interactive protein,cPLA（2） interacting protein,cPLA（2）-interacting protein,cPLA2,cPLA2 interacting protein,ESA1,Histone acetyltransferase HTATIP,Histone acetyltransferase KAT5,HIV 1 Tat interactive protein,HIV 1 Tat interactive protein,60kDa,HIV-1 Tat interactive protein,HTATIP,HTATIP1,K（lysine） acetyltransferase 5,K-acetyltransferase 5,KAT5,KAT5,Lysine acetyltransferase 5,PLIP,Tat interacting protein,60kDa,TIP,Tip60
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human TIP60 around the phosphorylation site of Ser86
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：40000
Gene_ID（human）：10524
Swissprot：Q92993
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Microbiology
