Background：c-Jun N-terminal kinases （JNKs） phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1 and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2 and JNK3b2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 （PRKM8, SAPK1, MAPK8） gene maps to chromosome 10q11.22 and shares 83％ amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T （TH） cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides （NOx） upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.
仕様
Synonyms：MAPK8,JNK1,PRKM8,SAPK1,SAPK1C,Mitogen-activated protein kinase 8,MAP kinase 8,MAPK 8,JNK-46,Stress-activated protein kinase 1c,SAPK1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1,MAPK9,JNK2,PRKM9,SAPK1A,Mi
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Tyr185
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：50-1：200, ELISA 1：10000-1：20000
Gene_ID（human）：5599/5601/5602
Swissprot：P45983,P45984,P53779
Isotype：IgG
Research Areas：Cancer, Immunology, Signal transduction
