Background：Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB （cAMP response element-binding protein） and ATF1 （activating transcription factor-1）. Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor （EGF）, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 （HMG-14）.
仕様
Synonyms：90 kDa ribosomal protein S6 kinase 5,EC 2.7.11.1,KS6A5,MGC1911,Mitogen and stress activated protein kinase 1,MSPK1,Nuclear Mitogen And Stress Activated Protein Kinase 1,Nuclear mitogen- and stress-activated protein kinase 1,Ribosomal protein S6 kinase 90kD polypeptide 5,Ribosomal protein S6 kinase 90kDa,Ribosomal protein S6 kinase 90kDa polypeptide 5,Ribosomal Protein S6 Kinase Alpha 5,Ribosomal protein S6 kinase alpha-5,RLPK,RPS6KA5,RSK Like Protein Kinase,RSK-like protein kinase,RSKL,S6K alpha 5,S6K-alpha-5
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human MSK1 around the phosphorylation site of Ser376
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IF 1：100-1：300, ELISA 1：20000
Gene_ID（human）：9252
Swissprot：O75582
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
