Background：May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
仕様
Synonyms：CAP20,CDK-interacting protein 1,CDKI,CDKN1,Cdkn1a,CDN1A,CIP1,Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A （P21）,Cyclin-dependent kinase inhibitor 1A （p21,Cip1）,DNA Synthesis Inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,Melanoma differentiation-associated protein,p21,P21 protein,p21CIP1,p21Cip1/Waf1,p21WAF,PIC1,SDI1,SLC12A9,WAF1,Wild type p53 activated fragment 1 （WAF1）,Wild type p53 activated fragment 1,Wildtype p53-activated fragment 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human p21 around the phosphorylation site of Thr145
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
