Background：Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
仕様
Synonyms：I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
Host：Rabbit
Reactivity：Human,Mouse,Rat,Monkey
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human IkappaB-a around the phosphorylation site of Ser32/36
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：4792
Swissprot：P25963
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
