Background：DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
仕様
Synonyms：Docking protein 1 62kD,Docking protein 1,DOK 1,DOK1,DOK1,Downstream of tyrosine kinase 1,p62（dok）,P62DOK,pp62
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Dok-1 around the phosphorylation site of Tyr362
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IF 1：100-1：300, ELISA 1：10000
Gene_ID（human）：1796
Swissprot：Q99704
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
