Background：Histone H2A.Z/H2A.F/Z （H2A/z） is a 128 amino acid protein encoded by the human gene H2AFZ. Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA sequentially in a left-handed super-helical turn to form chromosomal fiber. Two molecules of each of the four core histones （H2A, H2B, H3 and H4） form the octamer, which is comprised of two H2A-H2B dimers and two H3-H4 dimers, creating two nearly symmetrical halves by tertiary structure. H2A.Z/H2A.F/Z is a variant Histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of posttranslational modifications of histones, also called histone code, and nucleosome remodeling. H2A.Z/H2A.F/Z may be involved in the formation of constitutive heterochromatin and may be required for chromosome segregation during cell division.
仕様
Synonyms：H2A histone family member Z,H2A.z,H2A/z,H2afz,H2AZ,H2AZ,Histone H2A.Z,MGC117173
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/mL
Immunogen：Synthetic Peptide
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：1000-2000
Gene_ID（human）：3015
Swissprot：P0C0S5
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
