Background：BMAL1, a basic helix–loop–helices with Per–Arnt–Sim （PAS） domain transcription factor, is one of components that has core clock function in mammals. It form a heterodimer with CLOCK, and induce the transcription of target genes by binding to E-box elements within their promoter regions. And this transcription is inhibited in a feedback loop by PER, and also by CRY proteins.Also BMAL1 is a key player in the regulation of metabolism, playing a role in adipogenesis and in the control of glucose and triglycerides levels.
仕様
Synonyms：ARNT like protein 1 brain and muscle,Arntl,Aryl hydrocarbon receptor nuclear translocator like,Aryl hydrocarbon receptor nuclear translocator like protein 1,Aryl hydrocarbon receptor nuclear translocator-like protein 1,Basic helix loop helix PAS orphan MOP3,Basic helix loop helix PAS protein MOP3,Basic-helix-loop-helix-PAS protein MOP3,bHLH PAS protein JAP3,bHLH-PAS protein JAP3,bHLHe5,BMAL 1,BMAL1,BMAL1c,Brain and muscle ARNT like 1,Brain and muscle ARNT-like 1,CG8727 PA,Class E basic helix-loop-helix protein 5,cycle,JAP 3,JAP3,Member of PAS protein 3,Member of PAS superfamily 3,MGC47515,MOP 3,MOP3,PAS domain-containing protein 3,PASD 3,PASD3,TIC
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human BMAL1 around the acetylation site of K538.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：20000
Gene_ID（human）：406
Swissprot：O00327
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience
