Background：This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
仕様
Synonyms：Alpha 1 type II collagen,Alpha-1 type II collagen,AOM,Cartilage collagen,Chondrocalcin,CO2A1,COL11A3,Col2a1,Collagen II alpha 1 polypeptide,SEDC
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Synthetic Peptide of Collagen II
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：1H1
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide and 50％ glycerol pH 7.4.
Dilution：IHC 1：50-300
Gene_ID（human）：1280
Swissprot：P02458
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
