Background：Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
仕様
Synonyms：5 AMP activated protein kinase alpha 1catalytic subunit,5 AMP activated protein kinase catalytic alpha 1 chain,5' AMP activated protein kinase catalytic subunit alpha 1,5'-AMP-activated protein kinase catalytic subunit alpha-1,AAPK1,AAPK1,ACACA kinase,acetyl CoA carboxylase kinase,AI194361,AI450832,AL024255,AMP -activate kinase alpha 1 subunit,AMP-activated protein kinase,catalytic,alpha -1,AMPK 1,AMPK alpha 1,AMPK alpha 1 chain,AMPK,AMPK subunit alpha-1,AMPK1,AMPKa1,AMPKalpha1,C130083N04Rik,cb116,EC 2.7.11.1,HMG CoA reductase kinase,HMGCR kinase,hormone sensitive lipase kinase,Hydroxymethylglutaryl CoA reductase kinase,im：7154392,kinase AMPK alpha1,MGC33776,MGC57364,OTTHUMP00000161795,OTTHUMP00000161796,PRKAA 1,PRKAA1,Protein kinase AMP activated alpha 1 catalytic subunit,SNF1-like protein AMPK,SNF1A,Tau protein kinase PRKAA1,wu：fa94c10
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p
Concentration：1mg/mL
Immunogen：Recombinant Protein of AMPKa1 of PRKAA1
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：9G3
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：1000-2000, IHC 1：100-200
Gene_ID（human）：5562
Swissprot：Q13131
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
