Background：This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain （CSD） which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
仕様
Synonyms：Antigen p25,CBX5,CBX5,CG8409,Chromobox 5,Chromobox homolog 5 （HP1 alpha homolog,Drosophila）,Chromobox homolog 5,Chromobox protein homolog 5,Epididymis luminal protein 25,HEL25,Heterochromatin protein 1 alpha,Heterochromatin protein 1,Heterochromatin protein 1 homolog alpha,HP1 alpha,HP1 alpha homolog,HP1,HP1A,HP1Hs alpha,Su（var）205
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p
Concentration：1mg/mL
Immunogen：Recombinant Protein of HP-1a
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：7B6
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：500-2000, IHC 1：50-300
Gene_ID（human）：23468
Swissprot：P45973
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Tags ＆ Cell Markers
