Background：Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein （C/EBP） function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription： dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase （ASNS）, CEBPA-dependent transcriptional activation of hepcidin （HAMP） and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma （PPARG）. Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 （CASP4/CASP11） which induces the activation of caspase-1 （CASP1） and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
仕様
Synonyms：C/EBP homologous protein,C/EBP Homology Protein,C/EBP zeta,C/EBP-homologous protein 10,C/EBP-homologous protein,CCAAT/enhancer binding protein homologous protein,CEBPZ,CHOP 10,CHOP,CHOP-10,CHOP10,DDIT 3,DDIT-3,Ddit3,DDIT3,DNA Damage Inducible Transcript 3,DNA damage-inducible transcript 3 protein,GADD 153,GADD153,Growth Arrest and DNA Damage Inducible Protein 153,Growth arrest and DNA damage inducible protein GADD153,Growth arrest and DNA damage-inducible protein GADD153,MGC4154
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF
Concentration：1mg/mL
Immunogen：Synthetic Peptide of CHOP
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：4C3
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：200, IF 1：100-1：300
Gene_ID（human）：1649
Swissprot：P35638
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Developmental biology, Stem cells
