Background：This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.MICU1 （Mitochondrial Calcium Uptake 1） is a Protein Coding gene. Diseases associated with MICU1 include Myopathy With Extrapyramidal Signs and Fish Allergy. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3.
仕様
Synonyms：Allergen Hom s 4,ara CALC,atopy related autoantigen,atopy related autoantigen CALC,Atopy-related autoantigen CALC,CALC,calcium binding atopy related autoantigen 1,Calcium uptake protein 1,calcium uptake protein 1,mitochondrial,Calcium-binding atopy-related autoantigen 1,CBARA1,EFHA3,FLJ12684,MICU1,MICU1,mitochondrial,mitochondrial calcium uptake 1,MPXPS
Host：Mouse
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF
Concentration：1mg/mL
Immunogen：Recombinant Protein
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：4E7
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：200, IF 1：100-1：300
Gene_ID（human）：10367
Swissprot：Q9BPX6
Isotype：IgG
Research Areas：Cancer, Metabolism, Immunology, Signal transduction
