Background：Involved in DNA non-homologous end joining （NHEJ） required for double-strand break repair and V（D）J recombination. Binds to DNA and to DNA ligase IV （LIG4）. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
仕様
Synonyms：DNA double strand break repair and V（D）J recombination protein XRCC4,DNA repair protein XRCC4,SSMED,X ray repair complementing defective repair in Chinese hamster cells 4,X ray repair cross complementing 4,X ray repair cross complementing protein 4,X-ray repair cross-complementing protein 4,XRCC 4,XRCC4,XRCC4
Host：Mouse
Reactivity：Human
Applications：WB,IHC-p,IF,IP
Concentration：1mg/mL
Immunogen：Synthetic Peptide
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：8K2
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：50-300, IF 1：50-1：200, IP 1：100-1：300
Gene_ID（human）：7518
Swissprot：Q13426
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
