Background：May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen （growth） state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
仕様
Synonyms：39.1,CK 17,CK-17,Cytokeratin-17,K17,K1C17,Keratin 17,keratin 17 epitope S1,keratin 17 epitope S2,keratin 17 epitope S4,Keratin 17,type I,Keratin,Keratin type I cytoskeletal 17,keratin,type i cytoskeletal 17 [version 1],Keratin-17,KRT17,PC,PC2,PCHC1,type I cytoskeletal 17
Host：Mouse
Reactivity：Human
Applications：WB,IHC-p,IF,IP
Concentration：1mg/mL
Immunogen：Synthetic Peptide
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：2K5
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：50-300, IF 1：50-1：200, IP 1：100-1：300
