Background：The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin （KRT6） have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
仕様
Synonyms：CK-6A,CK-6D,CK6A,CK6C,CK6D,Cytokeratin-6A,Cytokeratin-6D,K2C6A,K6A,K6C,K6D,keratin 6A,Keratin,Keratin,type II cytoskeletal 6A,Keratin-6A,Krt6a,KRT6C,KRT6D,type II cytoskeletal 6A,Type-II keratin Kb6
Host：Mouse
Reactivity：Human
Applications：WB,IHC-p,IF
Concentration：1mg/mL
Immunogen：Synthetic Peptide
Purification Method：Protein A purification
Clonality：Monoclonal
Clone No.：3B6
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：50-300, IF 1：100-1：300
Gene_ID（human）：3854/286887/3853
Swissprot：P02538,P04259,P48668
Isotype：IgG
Research Areas：Cancer, Signal transduction, Tags ＆ Cell Markers
