Background：The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
仕様
Synonyms：NBLST2,NBPhox,Neuroblastoma paired type homeobox protein,Neuroblastoma Phox,Paired like homeobox 2b,Paired mesoderm homeobox 2b,Paired mesoderm homeobox protein 2B,Paired-like homeobox 2B,PHOX 2B,PHOX 2B homeodomain protein,PHOX2B,PHOX2B homeodomain protein,PHX2B,PMX 2B,PMX2B
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human PHOX2B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：8929
Swissprot：Q99453
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience
