Background：The protein encoded by this gene is a member of the signal-regulatory-protein （SIRP） family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases （PTP）, and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
仕様
Synonyms：Signal regulatory protein alpha type 1,Bit,Brain Ig like molecule with tyrosine based activation motifs,Brain Ig-like molecule with tyrosine-based activation motifs,Brain immunoglobulin like molecule with tyrosine based activation motifs,CD172 antigen like family member A,CD172 antigen-like family member A,CD172a,CD172a antigen,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MFR,MYD 1,Myd 1 antigen,MyD-1 antigen,p84,Protein tyrosine phosphatase non receptor type substrate 1,PTPNS1,SHP substrate 1,SHPS-1,SHPS1,SHPS1,Signal regulatory protein alpha 2,Signal regulatory protein alpha 3,Signal regulatory protein alpha,Signal regulatory protein alpha type 2,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,Signal-regulatory protein alpha-3,SIRP,Sirp-alpha-1,Sirp-alpha-2,Sirp-alpha-3,SIRPA,SIRPalpha,SIRPalpha1,SIRPalpha2,SIRPalpha3,Tyrosine phosphatase SHP substrate 1,Tyrosine protein phosphatase non receptor type substrate 1,Tyrosine-protein phosphatase non-receptor type substrate 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human SIRPA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：2000
Gene_ID（human）：140885
Swissprot：P78324
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Neuroscience
