Background：This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ （PSD-95/Discs large/ZO-1 homologous） domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus （HTLV1） Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 （Kir2.3）. To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仕様
Synonyms：Glutaminase interacting protein 3,Glutaminase-interacting protein 3,Tax interaction protein 1,Tax1 （human T cell leukemia virus type I） binding protein 3,Tax1 binding protein 3,Tax1-binding protein 3,Tax1bp3,TIP 1,TIP-1,TIP1,TX1B3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TAX1BP3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：30851
Swissprot：O14907
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction, Stem cells
