Background：This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
仕様
Synonyms：bccip,BCCIP,BCCIPalpha,BCCIPbeta,BRCA2 and CDKN1A interacting protein,BRCA2 and CDKN1A-interacting protein,BRCA2 and Cip1/p21 interacting protein,Cdk inhibitor p21 binding protein,P21 and CDK associated protein 1 ,P21- and CDK-associated protein 1,Protein TOK-1,Protein TOK1,TOK 1,TOK 1alpha,TOK 1beta,TOK1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human BCCIP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：56647
Swissprot：Q9P287
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
