Background：This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
仕様
Synonyms：Cytochrome P450 Family 46 Subfamily A Member 1,Cytochrome P450, Subfamily 46 （Cholesterol 24-Hydroxylase）,Cytochrome P450, Family 46, Subfamily A, Polypeptide 1,Cytochrome P450 46A1,CYP46,CH24H,Cholesterol 24-Hydroxylase,EC 1.14.14.25,CP46.
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CYP46A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：10858
Swissprot：Q9Y6A2
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
