Background:The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.
仕様
Synonyms:bA188C12.1,DKFZp667M072,EHMT 1,EHMT1,EHMT1,Eu-HMTase1,Euchromatic histone lysine N methyltransferase 1,Euchromatic histone methyltransferase 1,Euchromatic histone-lysine N-methyltransferase 1,EUHMTASE1,FLJ12879,FP13812,G9a like protein 1,G9a like protein,G9a-like protein 1,GLP 1,GLP,GLP1,H3 K9 HMTase 5,H3-K9-HMTase 5,Histone H3 K9 methyltransferase 5,Histone H3-K9 methyltransferase 5,Histone lysine N methyltransferase H3 lysine 9 specific 5,Histone-lysine N-methyltransferase EHMT1,KIAA1876,Lysine N methyltransferase 1D,Lysine N-methyltransferase 1D,RP11 188C12.1
Host:Rabbit
Reactivity:Human,Mouse,Rat
Applications:WB
Concentration:1mg/ml
Immunogen:Recombinant protein of human EHMT1
Purification Method:Affinity purification
Clonality:Polyclonal
Conjugation:Unconjugated
Buffer:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Dilution:WB1:500 - 1:2000
Gene_ID(human):79813
Swissprot:Q9H9B1
Isotype:IgG
Research Areas:Cancer, Epigenetics and Nuclear Signaling