Background：The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
仕様
Synonyms：ABC member 16,MDR/TAP subfamily,ABC16,ABCB1,Abcb11,ABCBB,ATP binding cassette sub family B （MDR/TAP） member 11,ATP binding cassette sub family B member 11,ATP-binding cassette sub-family B member 11,Bile salt export pump,BRIC2,Bsep,PFIC 2,PFIC2,PGY4,progressive familial intrahepatic cholestasis 2,Sister of P glycoprotein,Spgp
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human ABCB11
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：8647
Swissprot：O95342
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
