Background：This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
仕様
Synonyms：Circadian clock protein PERIOD 1,Circadian clock protein PERIOD1,Circadian pacemaker protein Rigui,hPER 1,hPER,hPER1,KIAA0482,MGC88021,PER 1,PER,PER1,PER1 protein,PER1,Period 1,Period circadian protein homolog 1,Period drosophila homolog of,Period homolog 1,Period1,RIGUI
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human PER1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：5187
Swissprot：O15534
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Neuroscience
