Background：Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis （ALS） has been associated with mutations in this gene.
仕様
Synonyms：200 kDa neurofilament protein,CMT2CC,Nefh,Neurofilament heavy polypeptide 200kDa,Neurofilament heavy polypeptide,Neurofilament triplet H protein,NF H,NF-H,NFH,NFH
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human NEFH
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：4744
Swissprot：P12036
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
