Background：This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
仕様
Synonyms：AI047818,CATC,CATC,Cathepsin C,Cathepsin J,CPPI,CTSC,Dipeptidyl peptidase 1,Dipeptidyl peptidase 1 light chain,Dipeptidyl peptidase I,Dipeptidyl peptidase I exclusion domain chain,Dipeptidyl peptidase I heavy chain,Dipeptidyl peptidase I light chain,Dipeptidyl transferase,DPP I,DPP-I,DPPI,EC 3.4.14.1,HMS,JP,JPD,MGC126959,PALS,PDON1,PLS
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CTSC
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
