Background：This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.
仕様
Synonyms：CTG 26,CTG repeat protein 26,CTG26,N CoR2,N-CoR2,NCoR 2,Ncor2,NCOR2,Nuclear Receptor Co-Repressor 2,Nuclear receptor corepressor 2,retinoic-acid-receptor-associated corepressor,Silencing Mediator for Retanoid and Thyroid Hormone Receptors,Silencing mediator of retinoic acid and thyroid hormone receptor,SMAP 270,SMAP270,SMRT,SMRTE,SMRTE tau,T3 receptor associating factor,T3 receptor-associating factor,Thyroid retinoic acid receptor associated corepressor,Thyroid-,TNRC 14,TNRC14,TRAC 1,TRAC,TRAC1
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human NCOR2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：9612
Swissprot：Q9Y618
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
