Background：This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs （SKP1-cullin-F-box）, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes： Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：0610033L19Rik,1600016C16Rik,F box only protein 22,F box protein 22,F box protein FBX22p44 ,F-box only protein 22,F-box protein FBX22p44,FBX22,FBX22,FBXO 22,FBXO22,FIST domain containing 1,FISTC1,FLJ13986,MGC124731,MGC31799
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human FBXO22
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：26263
Swissprot：Q8NEZ5
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
