Background：The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal （BRCT） motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
仕様
Synonyms：Homologue to Drosophila photoreceptor protein calphotin,MDC 1,Mdc1,MDC1,Mediation of DNA damage checkpoint 1,Mediator of DNA damage checkpoint 1,Mediator of DNA damage checkpoint protein 1,NFBD 1,NFBD1,Nuclear factor with BRCT domains 1,Nuclear Factor with BRCT Domains Protein 1
Host：Rabbit
Reactivity：Human
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human MDC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：9656
Swissprot：Q14676
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
