Background：This gene encodes a ribonuclease （RNase） III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA （miRNA） synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA （pri-miRNA） in the nucleus, yielding the precursor miRNA （pre-miRNA）, which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
仕様
Synonyms：DROSHA,Drosha double stranded RNA specific endoribonuclease,Drosha ribonuclease type III,Etohi2,HSA242976,Nuclear RNase III Drosha,p241,Protein Drosha,Putative protein p241 which interacts with transcription factor Sp1,Putative ribonuclease III,RANSE3L,Ribonuclease 3,Ribonuclease III,Ribonuclease III nuclear,Ribonuclease type III nuclear,RibonucleaseIII,RN 3,RN3,RNase 3,RNase III,RNase3,RNASE3L,RNaseIII,RNASEN,RNC
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human DROSHA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：29102
Swissprot：Q9NRR4
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
