Background：Cytochrome c oxidase （COX）, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.
仕様
Synonyms：COX7a related protein,COX7a-related protein,COX7A2L,COX7AR,COX7R,COX7RP,Cytochrome c oxidase subunit 7A-related protein,cytochrome c oxidase subunit 7A-related protein, mitochondrial,Cytochrome c oxidase subunit 7A2 like,cytochrome c oxidase subunit VII-related protein,cytochrome c oxidase subunit VIIa polypeptide 2 like,Cytochrome c oxidase subunit VIIa related protein, mitochondrial,Cytochrome c oxidase subunit VIIa-related protein,EB1,Estrogen receptor binding CpG island,mitochondrial,SIG81
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human COX7A2L
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：9167
Swissprot：O14548
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
