Background：This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF（II）31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia （FA） core complex, the APITD1/CENPS complex, and the CENPA-CAD （nucleosome distal） complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin （CORT） gene, as represented in GeneID：100526739. An APITD1-related pseudogene has been identified on chromosome 7.
仕様
Synonyms：APITD1,Apoptosis-inducing TAF9-like domain-containing protein 1,apoptosis-inducing, TAF9-like domain 1,CENP-S,CENPS,CENPS,Centromere protein S,FAAP16,FANCM-interacting histone fold protein 1,Fanconi anemia-associated polypeptide of 16 kDa,MGC32686,MHF 1
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human APITD1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：100526739
Swissprot：Q8N2Z9
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
