Background：This gene encodes a protein that contains four domains present in other developmental proteins： a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome （WHS） is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t（4;14）（p16.3;q32.3） in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA （NMD） decay candidates, hence not represented as reference sequences.
仕様
Synonyms：FLJ23286,IL5 promoter REII region binding protein,KIAA1090,MGC176638,MMSET,MMSET type II,Multiple myeloma SET domain containing protein type III,Multiple myeloma SET domain protein,Multiple myeloma SET domain-containing protein,NSD 2,NSD2,NSD2,Nuclear receptor binding SET domain protein 2,Nuclear SET domain-containing protein 2,Probable histone-lysine N-methyltransferase NSD2,Protein trithorax-5,REIIBP,Trithorax/ash1 related protein 5,TRX5,TRX5 protein ,WHS,Whsc1,Wolf Hirschhorn syndrome candidate 1,Wolf Hirschhorn syndrome candidate 1 protein,Wolf-Hirschhorn syndrome candidate 1 protein
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human WHSC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：7468
Swissprot：O96028
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Tags ＆ Cell Markers
