Background：The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase （AMPK）. AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase （ACC） and beta-hydroxy beta-methylglutaryl-CoA reductase （HMGCR）, key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
仕様
Synonyms：1300015D22Rik,5''-AMP-activated protein kinase subunit beta-1,5'-AMP-activated protein kinase beta-1 subunit,AAKB1,AMP-activated protein kinase beta subunit,AMP-ACTIVATED PROTEIN KINASE,NONCATALYTIC,BETA-1,AMP-activated,noncatalytic,beta-1,AMPK,AMPK beta 1 chain,AMPK subunit beta-1,AMPK-BETA-1,AMPKb,AU021155,E430008F22,HAMPKb,MGC17785,PRKAB1,Protein kinase AMP activated non catalytic subunit beta 1,protein kinase,AMP-activated,beta 1 non-catalytic subunit,protein kinase,AMP-activated,noncatalytic,beta-1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PRKAB1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：5564
Swissprot：Q9Y478
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
