Background：This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
仕様
Synonyms：Octamer binding transcription factor 4,MGC22487,Oct 3,Oct 4,Oct-3,Oct-4,OCT3,Oct4,Octamer binding protein 3,Octamer binding protein 4,Octamer binding transcription factor 3,Octamer-binding protein 3,Octamer-binding protein 4,Octamer-binding transcription factor 3,OTF 3,OTF 4,OTF-3,OTF3,OTF4,PO5F1,POU class 5 homeobox 1,POU domain class 5 transcription factor 1,POU domain transcription factor OCT4,POU domain,class 5,transcription factor 1,POU-type homeodomain-containing DNA-binding protein,POU5F1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human POU5F1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：5460
Swissprot：Q01860
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Stem cells
