Background：This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases （PTP） and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA （pyogenic sterile arthritis, pyoderma gangrenosum, and acne） syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
仕様
Synonyms：CD2 antigen binding protein 1,CD2 binding protein 1,CD2 cytoplasmic tail binding protein,CD2-binding protein 1,CD2BP1,CD2BP1L,CD2BP1S,H PIP,H-PIP,HPIP,PAPAS,PEST phosphatase interacting protein 1,PEST phosphatase-interacting protein 1,PPIP1,Proline serine threonine phosphatase interacting protein 1,Proline-serine-threonine phosphatase-interacting protein 1,PSTPIP,Pstpip1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human PSTPIP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
