Background：This gene encodes a member of the vaccinia-related kinase （VRK） family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 （activating transcription factor 2） and c-JUN.
仕様
Synonyms：MGC117401,MGC138280,MGC142070,PCH1,PCH1A,Serine/threonine protein kinase VRK1,Serine/threonine-protein kinase VRK1,Vaccinia related kinase 1 ,Vaccinia virus B1R related kinase 1,Vaccinia-related kinase 1,VRK1,VRK1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human VRK1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：7443
Swissprot：Q99986
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
