Background：This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs （SKP1-cullin-F-box）, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes： Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B （CDKN1B, also referred to as p27 or KIP1） predominantly in S phase and interacts with S-phase kinase-associated protein 1 （SKP1 or p19）. In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
仕様
Synonyms：CDK2/Cyclin A associated protein p45,Cyclin A/CDK2 associated protein p45,Cyclin-A/CDK2-associated protein p45,F box protein Skp2,F box/LRR repeat protein 1,F-box protein Skp2,F-box/LRR-repeat protein 1,FBL 1,FBL1,FBXL 1,FBXL1,FLB 1,FLB1,MGC1366,p45,p45skp2,S phase kinase associated protein 2 （p45）,S phase kinase associated protein 2,S-phase kinase-associated protein 2,S-phase kinase-associated protein 2 E3 ubiquitin protein ligase,SKP 2,Skp2,SKP2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human SKP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：6502
Swissprot：Q13309
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular
