Background：This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest （p66Shc） may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：FLJ26504,p66,p66SHC,SH2 domain protein C1,SHC （Src homology 2 domain containing） transforming protein 1,SHC 1,SHC A,SHC adaptor protein 1,Shc,SHC transforming protein 1,SHC transforming protein,SHC-transforming protein 1,SHC-transforming protein 3,SHC-transforming protein A,SHC1,SHC1,SHCA,Src homology 2 domain-containing-transforming protein C1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human SHC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：6464
Swissprot：P29353
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
