Background：This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein （mRNP） complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes.
仕様
Synonyms：BP 8,CBF-A,CCAAT binding transcription factor I subunit A,CCAAT-binding transcription factor I subunit A,CSDA2,CSDB,DBPB,DNA binding protein B,DNA-binding protein B,EFI-A,Enhancer factor I subunit A,MDR NF1,MGC104858,MGC110976,MGC117250,NSEP 1,NSEP1,Nuclease sensitive element binding protein 1,Nuclease-sensitive element-binding protein 1,p50,Q15905,Y-box binding protein 1,Y-box transcription factor,Y-box-binding protein 1,YB 1,YB-1,YBOX1,YBX 1,ybx1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human YBX1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：4904
Swissprot：P67809
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Stem cells, Tags ＆ Cell Markers
