Background：Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
仕様
Synonyms：AT V1,AT V2,ATV,Cell cycle regulatory protein p95,FLJ10155,MGC87362,Nbn,NBN,NBS 1,NBS,NBS1,Nibrin,Nijmegen breakage syndrome 1 （nibrin）,Nijmegen breakage syndrome,Nijmegen breakage syndrome protein 1,p95,p95 protein of the MRE11/RAD50 complex
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human NBN
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：4683
Swissprot：O60934
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
