Background：Muscle myosin is a hexametric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta （or slow） heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha （or fast） heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
仕様
Synonyms：Beta myosin heavy chain,cardiac muscle beta isoform,CMD1S,CMH1,MPD1,MYH7,MYH7,Myhc slow,MyHC-beta,MyHC-slow,MYHCB,Myopathy,distal 1,Myosin heavy chain （AA 1-96）,Myosin heavy chain 7,Myosin heavy chain,Myosin heavy chain slow isoform,Myosin heavy chain,cardiac muscle beta isoform,Myosin,heavy chain 7,cardiac muscle,beta,Myosin,heavy polypeptide 7,cardiac muscle,beta,Myosin-7,Rhabdomyosarcoma antigen MU RMS 40.7A,SPMD,SPMM
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human MYH7
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：4625
Swissprot：P12883
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
