Background：This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
仕様
Synonyms：dJ281H8.4,IDDM5 ,Small ubiquitin like modifier 4 protein,Small ubiquitin-like protein 4,Small ubiquitin-related modifier 4,SMT3 suppressor of mif two 3 homolog 2,SMT3 suppressor of mif two 3 homolog 4 （S. cerevisiae）,SMT3H4 ,SUMO 4,SUMO-4,SUMO4,SUMO4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human SUMO4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：387082
Swissprot：Q6EEV6
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
