Background：This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein （CHMP） protein family. The protein is part of the endosomal sorting complex required for transport （ESCRT） complex III （ESCRT-III）, which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein （PDCD6IP, also known as ALIX）, which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
仕様
Synonyms：Charged multivesicular body protein 4b,CHM4B,chmp4b,Chromatin-modifying protein 4b,hSnf7-2,hVps32-2,SNF7 homolog associated with Alix 1,SNF7-2,Vacuolar protein sorting-associated protein 32-2,Vps32-2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CHMP4B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：128866
Swissprot：Q9H444
Isotype：IgG
Research Areas：Cancer, Cell Biology, Microbiology, Signal transduction
