Background：This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：Acute myeloid leukemia 2 protein,Acute myeloid leukemia gene 2,AML 2,AML2,CBF alpha 3,CBF-alpha-3,CBFA 3,CBFA3,Core binding factor alpha 3 subunit,core binding factor,Core binding factor runt domain alpha subunit 3,Core binding factor subunit alpha 3,core-binding factor,Core-binding factor subunit alpha-3,Oncogene AML 2,Oncogene AML-2,PEA2 alpha C,PEA2-alpha C,PEBP2 alpha C,PEBP2-alpha C,Pebp2a3,PEBP2aC,Polyomavirus enhancer binding protein 2 alpha C subunit,Polyomavirus enhancer-binding protein 2 alpha C subunit,runt domain alpha subunit 3,runt related transcription factor 3,Runt-related transcription factor 3,RUNX 3,Runx3,RUNX3,SL3 3 enhancer factor 1 alpha C subunit,SL3-3 enhancer factor 1 alpha C subunit,SL3/AKV core binding factor alpha C subunit,SL3/AKV core-binding factor alpha C subunit,Transcription factor AML2
Host：Rabbit
Reactivity：Human
Applications：IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human RUNX3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：IF1：50 - 1：100
Gene_ID（human）：864
Swissprot：Q13761
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
