Background：This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family （Ikaros, Aiolos and Helios） are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
仕様
Synonyms：AIO,Aiolos,IKAROS family zinc finger 3 （Aiolos）,IKAROS family zinc finger 3,Ikaros family zinc finger protein 3,IKZF 3,IKZF3,IKZF3,zinc finger DNA binding protein Aiolos,Zinc finger protein Aiolos,Zinc finger protein subfamily 1A 3 （Aiolos）,Zinc finger protein subfamily 1A 3,Zinc finger protein subfamily 1A,member 3,ZNFN1A3
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human IKZF3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：100
Gene_ID（human）：22806
Swissprot：Q9UKT9
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
