Background:The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
仕様
Synonyms:B cell CLL/lymphoma 6,B cell lymphoma 6 protein,B-cell lymphoma 5 protein,B-cell lymphoma 6 protein,BCL 5,Bcl 6,BCL-5,BCL-6,BCL5,BCL6,BCL6,BCL6A,cys his2 zinc finger transcription factor,LAZ 3,LAZ 3 protein,LAZ3,Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3),Lymphoma associated zinc finger gene on chromosome 3,Protein LAZ-3,ZBTB 27,ZBTB27,Zinc finger and BTB domain containing protein 27,Zinc finger and BTB domain-containing protein 27 (ZBTB27),Zinc finger and BTB domain-containing protein 27,Zinc Finger Protein 51 (ZNF51),Zinc finger protein 51,zinc finger transcription factor BCL6S,ZNF 51,ZNF51
Host:Rabbit
Reactivity:Human,Mouse,Rat
Applications:WB,IF
Concentration:1mg/ml
Immunogen:Recombinant protein of human BCL6
Purification Method:Affinity purification
Clonality:Polyclonal
Conjugation:Unconjugated
Buffer:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Dilution:WB1:500 - 1:2000 IF1:50 - 1:100
Gene_ID(human):604
Swissprot:P41182
Isotype:IgG
Research Areas:Cancer, Epigenetics and Nuclear Signaling