Background：The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 （Smad2） and its nuclear partner forkhead box H1 （also known as FAST-1）, and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：COXPD17,elaC homolog 2 （E. coli）,ElaC homolog protein 2,elaC ribonuclease Z 2,elaC,E. coli,homolog of,2,ELAC2,ELC2,FLJ10530,FLJ36693,FLJ42848,Heredity prostate cancer protein 2,HPC2,putative prostate cancer susceptibility protein HPC2/ELAC2,Ribonuclease Z 2,Ribonuclease Z,long form,Ribonuclease Z2,RNase Z 2,RNase Z2,RNase ZL,RNZ2,tRNA 3 endonuclease 2,tRNase Z （long form）,tRNase Z 2,tRNase Z2,Zinc phosphodiesterase ELAC protein 2
Host：Rabbit
Reactivity：Human
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human ELAC2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：60528
Swissprot：Q9BQ52
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
