Background：This gene is a member of the leukocyte immunoglobulin-like receptor （LIR） family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs （ITIMs）. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：CD85 antigen-like family member K,CD85k,HM18,ILT-3,ILT3,Immunoglobulin-like transcript 3,Leukocyte immunoglobulin like receptor subfamily B （with TM and ITIM domains） member 4,Leukocyte immunoglobulin-like receptor 5,Leukocyte immunoglobulin-like receptor subfamily B member 4,LILRB4,LILRB5,LIR-5,LIR5,LIRB4,Monocyte inhibitory receptor HM18
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human LILRB4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：11006
Swissprot：Q8NHJ6
Isotype：IgG
Research Areas：Cardiovascular, Epigenetics and Nuclear Signaling, Immunology
